E2F1 Induces Pituitary Tumor Transforming Gene (PTTG1) Expression in Human Pituitary Tumors
نویسندگان
چکیده
منابع مشابه
Human pituitary tumor-transforming gene induces angiogenesis.
Angiogenesis is a key determinant and rate-limiting step in tumor progression and metastatic spread. As pituitary tumor-transforming gene (PTTG) induces basic fibroblast growth factor (bFGF), we tested angiogenesis induced by conditioned medium (CM) derived from NIH-3T3 transfectants overexpressing wild-type human PTTG (WT-hPTTG-CM). We also examined the relationship between PTTG expression and...
متن کاملexpression of the pituitary tumor transforming gene (pttg1) in pheochromocytoma as a potential marker for distinguishing benign versus malignant tumors.
the distinction between malignant and benign pheochromocytoma has always been a diagnostic challenge over the last decades. to date, the only reliable criterion is metastasis. the aim of the present study was to investigate the possible expression of pituitary-tumor transforming gene (pttg1) and retinoblastoma (rb) in benign and malignant pheochromocytoma. paraffin blocks of 44 and 11 patients ...
متن کاملCorrelations of Pituitary Tumor Transforming Gene Expression with Human Pituitary Adenomas: A Meta-Analysis
OBJECTIVE Pituitary tumor transforming gene (PTTG) is an important paracrine growth factor involved in early lactotrope transformation and early onset of angiogenesis in pituitary hyperplasia. Emerging evidences have shown that PTTG expression may contribute to the etiology of pituitary adenomas; but individually published studies showed inconclusive results. This meta-analysis aimed to derive ...
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BACKGROUND Recently, a vertebrate securin [pituitary tumor transforming gene (PTTG) in humans] has been identified that inhibits sister chromatid separation and is involved in malignant transformation and tumorigenesis. Abundance of this protein would disrupt cell division, generate chromosomal instability and thereby increase cell susceptibility to acquisition of further mutations during subse...
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Different mutations in the human Crumbs homolog-1 (CRB1) gene cause a variety of retinal dystrophies, such as Leber congenital amaurosis, early onset retinitis pigmentosa (e.g., RP12), RP with Coats-like exudative vasculopathy, and pigmented paravenous retinochoroidal atrophy. Loss of Crb1 leads to displaced photoreceptors and focal degeneration of all neural layers attributable to loss of adhe...
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ژورنال
عنوان ژورنال: Molecular Endocrinology
سال: 2009
ISSN: 0888-8809,1944-9917
DOI: 10.1210/me.2009-0161